Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour Application

Stanford University

Overview

Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the risk of infection. Previous studies have suggested that antibiotics containing a preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox). The purpose of this research is to compare how quickly to the two commonly prescribed antibiotics eliminate bacteria from the eye surface.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Conditions

Conjunctical Flora

Interventions

gatifloxacin, moxifloxacinDRUG

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age- older than 50 years of age * Diagnosis- Cataract or had cataract surgery Exclusion Criteria: * Systemic or topical antibiotic treatment within 30 days * Use of systemic or topical steroids * Active ocular infection * Ocular surgery in the past 6 months * Allergy to fluoroquinolones

Outcomes

Primary Outcomes

Antibiotic killing of conjunctival bacterial flora 1 hour after application

Data from ClinicalTrials.gov

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