In this study, we will compare the safety and efficacy of 400 mcg sublingually administered misoprostol alone to standard surgical care for the treatment of incomplete abortion. This study will provide important data on the role of misoprostol in health services offering an array of treatments for incomplete abortion. Women could significantly benefit from a non-invasive treatment option for incomplete abortion. While safe surgical services are becoming more widespread, there is still a serious risk of complications from these procedures. Especially in developing countries, infection, hemorrhage and uterine damage are still too common. Medical treatment of incomplete abortion using misoprostol would be a tremendous step to reducing morbidity and mortality due to abortion complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,000
single dose of 400 mcg misoprostol administered sublingually
standard surgical treatment (dilation and curettage or manual vacuum aspiration)
Dandé District Hospital/Ziniaré District Hospital
Dande/Ziniare, Burkina Faso
El-Galaa Teaching Hospital
Cairo, Egypt
Shatby Maternity Hospital/Alexandria University
Shatby, Alexandria, Egypt
Cheikh Zayed Hospital
Nouakchott, Mauritania
Maternite Issaka Gazobi
Niamey, Niger
Centre de Sante Le Roi Baudouin
Guédiawaye, Senegal
Complete abortion without recourse to surgical intervention.
Time frame: follow up visit 7 days after initial treatment
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