Use of Donepezil for Treatment of Cocaine Dependence

Inclusion Criteria: * Non-treatment seeking, experienced cocaine users, who have used cocaine by smoking or intravenous injection within the four weeks prior to screening, and must supply a cocaine-positive urine obtained within four weeks of entry into the study. Exclusion Criteria: * Shows signs of psychostimulant toxicity, or has a history of a medical adverse reaction to cocaine or other psychostimulants, including loss of consciousness, chest pain, cardiac ischemia, or seizure. * Has a current psychiatric disorder other than drug abuse or dependence or dementia. * Meets the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for dependence to opiates, benzodiazepines, alcohol, or other sedative-hypnotics. * Has received opiate-substitution therapy (methadone or buprenorphine) within two months prior to enrollment. * Has current or past history of seizure disorder, including alcohol- or psychostimulant- related seizures, or family history of seizure disorder. * Has a diagnosis of adult asthma, or chronic obstructive pulmonary disease, including a history of acute asthma within the past two years, and those with current or recent (with the past two years) treatment with an inhaled or oral beta-adrenergic agonist. * Has had head trauma that resulted in neurological sequelae. * Has an unstable medical condition, which, in the judgement of investigators, would make participation hazardous.