Efficacy and Safety of NS2359 in Adults With Attention Deficit Hyperactivity Disorder

Inclusion Criteria: * Patients with the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview using the K-SADS-E adult ADHD module * Patients with a CGI Global Severity (GS) score ≥4 (moderate impairment) * The Patient provided written informed consent. * Non-lactating women of childbearing potential that used adequate contraception (i.e. the use of oral contraceptives and practising a double-barrier form of birth control) and had a negative pregnancy test at screening. Women of no childbearing potential who had been postmenopausal for less than 2 years must have a negative pregnancy test at screening. Exclusion Criteria: * Any clinically unstable medical condition * Clinically significant abnormal baseline laboratory values * Mental retardation * Organic brain disorders * Non-febrile seizure disorder * Patients with a history of an eating disorder including anorexia or bulimia nervosa * Psychotic disorder of any type * Patients with a HAM-D (17 item) \>15 * Patients currently (within the past 6 months) known to abuse or to be dependent on any drug, including alcohol or a positive urine drug screen for cocaine, heroin, or marijuana * Treatment with stimulants was prohibited within 1 week prior to randomisation * Treatment with antipsychotics/neuroleptics was prohibited for 8 weeks prior to randomisation * Treatment with monoamine oxidase inhibitors was prohibited for 8 weeks prior to randomisation * Treatment with tricyclic antidepressants, histamines and selective serotonin reuptake inhibitors was prohibited for 4 weeks (fluoxetine for 6 weeks) prior to randomisation * Treatment with benzodiazepines, anticonvulsants (for behaviour) and lithium for 2 weeks prior to randomisation * Patients with a history of bipolar disorder * Patients using any concurrent medication for the treatment of ADHD * Patients that had previously participated in a NS2359 study * Patients treated with an investigational drug within 30 days or 5 half-lives (whichever is longer) preceding the first dose of study medication * Patients with a history of positive human immunodeficiency virus (HIV) test.