Effect of Androgel on Atherogenesis in Type 2 Diabetic Males With Hypogonadotrophic Hypogonadism

Inclusion Criteria: * Males with age 30-60 years inclusive. * PSA \< 2.6 ng/ml or \< 3.75 ng/ml with a negative prostate biopsy in the last 6 months. * IPSS ≤ 19. The lower age limit was decided on the fact that in our study on hypogonadotrophic hypogonadism in type 2 diabetic patients, the youngest subject was 31 years old. The upper age limit has been restricted to 60 to avoid including subjects with significant age-related declines in testosterone concentrations.Subjects on thiazolidinediones, statins, ACE inhibitors, angiotensin receptor blockers or antioxidants will be allowed as long as they are on stable doses of these compounds and the dosage in not changed during the study. Subjects on insulin, metformin or sulfonylureas can participate in the study, provided that minimal changes are made to the doses during the study Exclusion Criteria: * Coronary event or procedure (myocardial infarction, unstable angina, coronary artery bypass, surgery or coronary angioplasty) in the previous four weeks; 2)Hemoglobin A1c \>10%; * h/o prostate carcinoma; * Hepatic disease (transaminase \> 3 times normal) or cirrhosis; * Renal impairment (serum creatinine \> 1.5); * HIV or Hepatitis C positive status; * Participation in any other concurrent clinical trial; * Any other life-threatening, non-cardiac disease; * Use of over the counter health supplements which contain androgens; * Use of an investigational agent or therapeutic regimen within 30 days of study. * Use of testosterone in the past * Hematocrit \> 50%.