A Safety and Acceptability Study of a Vaginal Ring Microbicide Delivery Method

Inclusion Criteria: * Female, age 18-35 years * Willing and able to provide written informed consent * HIV-uninfected and otherwise healthy * Self-reported sexually active * On a stable hormonal contraceptive regimen * Regular menstrual cycle * Willing to refrain from use of vaginal products or objects during the study Exclusion Criteria: * Currently pregnant or last pregnancy within 3 months prior to enrollment * Currently breast-feeding * Participated in any other research study within 30 days prior to enrollment; * Symptomatic untreated vaginal infections within 2 weeks prior to enrollment * Presence of abnormal physical finding on the vulva, vaginal walls or cervix * History of significant urogenital or uterine prolapse, undiagnosed vaginal bleeding, urethral obstruction; * Pap smear result at screening that requires cryotherapy, biopsy, treatment (other than for infection), or further evaluation * Unexplained, undiagnosed abnormal bleeding per vagina, bleeding per vagina during or following vaginal intercourse, or gynecologic surgery within 90 days prior to enrollment * Any serious acute, chronic or progressive disease