Adalimumab in Severe and Acute Sciatica

Inclusion Criteria: 1. Male or female patients older than 18 2. Episode of radicular pain in one lower limb for less than 12 weeks. 3. Medical evaluation requiring hospitalisation because of pain or functional handicap 4. Patients presenting a characteristic leg pain in the L3, L4, L5, or S1 territories plus at least one of the following: : * positive straight-leg-raising test with an elevation of less than 70° * positive femoral stretched * clear clinical sign of nerve root involvement * muscle strength deficiency or * sensory disturbances in clear cut dermatome or * lower limb reflex asymmetry. 5. Oswestry score greater than 50 6. If there is a past history of radicular pain involving the same nerve root, a 6 months interval free of leg pain is required. 7. A confirmed herniated disc on usual imaging techniques (CT scan or MRI) in the vicinity of the clinically involved nerve root that has been performed within the last 2 years. 8. Written informed consent Exclusion Criteria: 1. The presence of recent (\<48 hours) severe muscle weakness (\<3/5) or clinical signs of cauda equina compression, requiring immediate surgery. * If surgical procedure is required but is denied, either because of surgeon's decision or because of patient's fully informed decision, then this patient could be included in the protocol. 2. Comorbidities such as : * Coexisting infections (Chest X-ray will be performed to all patients and tuberculin skin test in case of doubt concerning a past history of tuberculous infection). * Autoimmune disease (other than RA). * History of cancer or malign lymphoproliferative disorders (unless the patient has been declared in remission for more than 5 years) * History of demyelinating disorders. 3. Pregnancy. 4. History of intolerance to adalimumab or any of its ingredients 5. Previous participation in this clinical study. 6. Participation in another clinical study within 4 weeks prior to the start of or during this study. 7. Poor motivation or other emotional or intellectual problems that are likely to limit the ability of the patient to comply with the protocol requirements. 8. The use of cortisone prior to the inclusion IS NOT an exclusion criteria The investigators will also be allowed to exclude an individual patient from the study and remove the blinding in case of a superimposed infection or any severe side effect during the trial.