Feasibility Study: Accuracy of Biomarker in Detection of Endometrial Cancer

Dick Domanik20 enrolled

Overview

This study aims at developing an accurate, simple, and cost-effective method for screening and early detection of uterine cancers

The present study aims at developing an accurate, simple and cost-effective method for screening and early detection of uterine cancers in women using novel inventions and biotechnology methods for collection and assay of uterine cells. Results of P2X7 assays using tissues obtained from women with known uterine cancer and from women with histologically normal endometrium will be compared. These data will also serve as basis for future studies to test the predictive value of the method in population-based studies.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Uterine Cancer Endometrial Cancer

Interventions

P2x7 assayOTHER

compare P2X7 assay to biopsy

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * women scheduled to undergo hysterectomy * ages 18 years and older Exclusion Criteria: * pregnant women * students or employees under the direct supervision on the investigators.

Locations (5)

University of Arkansas

Little Rock, Arkansas, United States

University Hospital CASE Medical Center

Cleveland, Ohio, United States

University of Texas

Dallas, Texas, United States

University of Texas

Galveston, Texas, United States

Outcomes

Primary Outcomes

To determine the accuracy potential of the P2X7 (protein and mRNA levels) for the detection of uterine endometrial cancers in women.

Time frame: Upon review of the assays.

Data from ClinicalTrials.gov

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