Six Months DHEA Treatment in Female Adrenal Failure

N/ACompletedNCT00471900

University of Aarhus10 enrolled

Overview

DHEA is an adrenal deriven androgen precourser. The impact of DHEA substitution therapy in adrenal failure is unknown as well as the physiologically effects of DHEA is unknown. Effects of physiologically DHEA substitution is investigated in the model of female adrenal failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Adrenal Insufficiency

Interventions

dehydroepiandrosterone (DHEA)DRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female, * Adrenal insuficiency, * Stable and safe anticonception, * Stable hydrocortison substituation treatment. Exclusion Criteria: * Neoplastic and thromboembolic disease, * Diabetes mellitus.

Outcomes

Primary Outcomes

Quality of life parameteres, cardiovascular parameters, bodycomposition, exercise parameters, hormonal and serological parameters, fuel metabolisme.

Time frame: six months

Data from ClinicalTrials.gov

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