Oxaliplatin + 5-FluoroUracil/LeucoVorin (5-FU/LV) (FOLFOX4) Versus Doxorubicin as Palliative Chemotherapy in Advanced Hepatocellular Carcinoma Patients

Inclusion Criteria: * Histologically, cytologically or clinically diagnosed (in patient with cirrhosis, Alpha-Fetoprotein(AFP)≥400μg/L and morphological evidence \[contrast Computed Tomography(CT)/Magnetic Resonance Imaging(MRI)\] of hypervascular liver tumor, elevated AFP level due to other reasons \[germ cell carcinoma, progressive chronic hepatitis, pregnancy, etc\] can be excluded) unresectable hepatocellular carcinoma, ineligible or if the patient does not consent to receive local invasive treatment (chemo-embolism, ablation, etc.). * At least one measurable lesion (on CT: ≥2cm, on spiral CT or MRI ≥1cm) * Have not received previous palliative systemic chemotherapy for metastatic disease. If the patient received previous systemic chemotherapy as adjuvant treatment, he must have been completed at least 12 months previously. * Patients progress after previous local treatment and at the time of randomization is at least 4 weeks after the last interventional therapy (Hepatic Artery Infusion, Trans-Artery Embolization or Trans-Artery Chemo-Embolization) or at least 8 weeks after the last radiotherapy/ablation/ Percutaneous Ethanol Injection to the target lesion. * Karnofsky Performance Score≥70, Barcelona of Cancer Liver Category stage B/C * Patients must have adequate organ and marrow function: * Neutrophilus≥1.5X10\^9/L * Platelets≥75X10\^9/L * Asparagine AminoTransferase,Alanine AminoTransferase\<2.5 Upper Normal Limit(UNL) * Total Bilirubin\<1.5 UNL * International Normalized Ratio\<1.5 * Child stage A or B * Normal base line Left Ventricular Ejection Fraction (LVEF result must be above or equal to the lower limit of normal for the institution) Exclusion Criteria: * Documented allergy to platinum compound or to other study drugs. * Any previous oxaliplatin or doxorubicin treatment, except adjuvant treatment more than 12 months before the randomization. * Previous liver transplantation. * Patients concomitantly receiving any other anti-cancer therapy, including interferon-α and herbal medicine which was approved by local authority to be used as "anti-cancer" medicine, except radiotherapy to non-target lesion (bone metastasis, etc) * Patients who are receiving any other study treatments. * Pregnant or lactating women or women of childbearing potential without proper contraceptive methods. * History of other malignant diseases, except cured basal cell carcinoma of skin and cured carcinoma in-situ of uterine cervix. * Central nervous system metastasis * Other serious illness or medical conditions The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.