The Precision and Arm-to-Arm Variation of Mechanomyography and Acceleromyography for Monitoring of Neuromuscular Block

Rigshospitalet, Denmark

Overview

The purpose of the study is the examine the precision of acceleromyography and mechanomyography during recovery from a neuromuscular blocking agent and to examine whether there is any difference in monitoring block at the dominant or non-dominant arm. Our hypothesis is that there is no significant difference in neither the precision nor the level of block in the contralateral arms.

Study Type

OBSERVATIONAL

Conditions

Neuromuscular Blockade

Interventions

TOF-Watch SX (neuromuscular monitor)DEVICE

The variation between arms (dominant or non-dominant) when monitored with the same method on both arms

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-III * General anesthesia \>1 hour * Surgery in supine position w. possibility of monitoring the neuromuscular block at both arms (n. ulnaris stimulation/thumb response) * Written informed content Exclusion Criteria: * Neuromuscular disorders, hepatic and renal dysfunction * Medication expected to interfere with the neuromuscular blocking agent * Allergy to any medication used during anaesthesia * Body weight less or exceeding 20% of ideal body weight * Pregnancy or breastfeeding

Locations (1)

Dep. of Anaesthesia

Copenhagen, Copenhagen, Denmark

Outcomes

Primary Outcomes

Precision at the contralateral arms using the average residual coefficient of variation over subsequent linear regressions (detrending) over time

Secondary Outcomes

Bias and limits of agreement between control TOF, reappearance of T1, T2, T3, T4

T1 height at reappearance of T1-T4

Time to T1=25%

Interval 25-75%

Time to TOF 0.9 and 1.0 with and without normalization

Time to stable T1 and stable TOF

Data from ClinicalTrials.gov

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