The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown. Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
13
to perform an i.v. lipid heparin infusion infusion for 4 h
Charite, Campus Benjamin Franklin
Berlin, Germany
change of DHEA
Measurement of serum DHEA
Time frame: 1 day
change of DHEAS
Measurement of serum DHEAS
Time frame: 1 day
change of testosterone
Measurement of serum testosterone
Time frame: 1 day
change of androstenedione
Measurement of serum androstenedione
Time frame: 1 day
urinary androgen excretion
Time frame: 1 day
urinary cortisol excretion
measurement of urinary cortisol, aTHF and THF
Time frame: 1 day
urinary cortisone excretion
measurement of urinary cortisone and THE
Time frame: 1 day
changes in metabolic parameters (e.g. FGF-21)
Time frame: 1 day
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