Older Adult Training Study With Creatine and CLA

Hamilton Health Sciences Corporation39 enrolled

Overview

We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (\> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Sarcopenia

Interventions

TrainingBEHAVIORAL

Creatine Monohydrate, Conjugated Linoleic AcidDRUG

Eligibility

Sex: ALLMin age: 65 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy, * Ambulatory, * Recreationally active, * Community dwelling Exclusion Criteria: * Evidence of coronary heart disease; * Congestive heart disease; * Uncontrolled hypertension; * Chronic obstructive pulmonary disease; * Diabetes mellitus; * Renal failure; * Major orthopedic disability; and * Smoking

Locations (1)

McMaster University Medical Center

Hamilton, Ontario, Canada

Outcomes

Primary Outcomes

a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption)

Time frame: six months

Secondary Outcomes

a. Functional capacity b. Strength with weight machines

Time frame: six months

Data from ClinicalTrials.gov

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