Preoperative Non-steroidal Anti-inflammatory Drugs(NSAID) to Colorectal Cancer Patients

Göteborg University28 enrolled

Overview

The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.

Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Colorectal Cancer

Interventions

Indomethacin, celecoxib, esomeprazoleDRUG

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Colon carcinoma scheduled for curative operation Exclusion Criteria: * Diabetes, steroid medication, liver and kidney impairment

Locations (1)

Department of Surgery

Gothenburg, Sweden

Outcomes

Primary Outcomes

Immune reactivity

Time frame: Acute evaluations

Data from ClinicalTrials.gov

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