AEGR-733 and Atorvastatin 20 mg vs. Monotherapy in Moderate Hypercholesterolemia

Inclusion Criteria: 1. Men and women between the ages of 18 and 70 years. 2. Elevated LDL cholesterol based on risk factors for cardiovascular disease or presence of cardiovascular disease Exclusion Criteria: 1. Women who are pregnant, lactating, planning to become pregnant, or women of childbearing potential who have not successfully been using acceptable contraceptive methods over the previous 3 months, e.g., intrauterine device (IUD) and barrier method plus spermicide. 2. Uncontrolled hypertension 3. History of chronic kidney problems 4. History of liver disease 5. Positive for Hepatitis B or Hepatitis C. 6. Any major surgical procedure occurring less than 3 months ago 7. Cardiac insufficiency 8. History of a malignant cancer (other than basal cell or squamous cell carcinoma of the skin that has been removed) within the previous 5 years. 9. Regular alcohol use \>1 drink per day. 10. Regular consumers of grapefruit juice, or currently taking the following medications: cyclosporine, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, and nefazodone. 11. Use of other cholesterol lowering medications that cannot be stopped. 12. Heart attack or stroke within the previous 6 months 13. Diabetes Mellitus 14. Body mass index (BMI) ≥ 40 kg/m2. 15. Significant gastrointestinal symptoms, such as irritable bowel syndrome. 16. Current use of fish oils, niacin, and herbal weight loss products that cannot be stopped.