Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease

Inclusion Criteria: 1. Patient with a complex perianal fistula. A complex perianal fistula must meet one of the following: * No fistula tract is palpated under the perianal skin or tract parallel to the rectum on examination with a stylet. * Associated anal incontinence in transsphincteric fistulas. * Risk factors for anal incontinence. * At least one prior surgery for a fistulous disease. * Suprasphincteric tracts shown by an image test. 2. Women of childbearing age should have a negative serum or urine pregnancy test (sensitive to 25IU of hCG) and not be lactating before study entry. Both men and women should use adequate birth control methods as defined by the investigator. 3. Seton presence is allowed at the time of study entry and until cells (in groups receiving ASCs) or Fibrin adhesive are implanted. 4. No condition that may prevent the patient from following the study procedures until 26 weeks of follow-up are completed is foreseen. 5. Patient should give his/her signed, written informed consent. - Exclusion Criteria: 1. Patient has been diagnosed with IBD 2. Patient has a rectovaginal fistula 3. Patient is pregnant or lactating woman 4. Patient has acute sepsis at the time of study entry 5. A liposuction to draw at least 100 cc of fat from the abdominal wall is not technically feasible. 6. Patient needs surgery in the perianal region for reasons other than fistulas 7. Presence of two or more complex perianal fistulas 8. Patient has collections \> 2 cm in MRI. If such collections exist, the surgeon may perform a complete toilette of the area. 9. Patient is allergic to local anesthetics or Gadolinium (MRI contrast agent). 10. MRI is not technically feasible. 11. Patient has abused alcohol or other addictive substances within 6 months of study entry. 12. Patient has active or latent infection by HIV, HBV or HCV. 13. Patient has undergone major surgery or sustained a severe trauma, in the investigator's judgment, within 28 days of recruitment. 14. Patient is receiving or has received immunomodulatory treatment for reasons other than the fistula within 6 months of study entry. 15. Patient has a malignant tumour, except for basal or squamous cell carcinoma of the skin, or has a prior history of a malignant tumour, except if the tumour has been in remission for at least the past 5 years. \-