Study of Genetic Polymorphisms in Thai HIV-1 Infected Patients on SQV/r

The HIV Netherlands Australia Thailand Research Collaboration250 enrolled

Overview

Study of genetic polymorphisms of CYP #A and MDR-1 genes in Thai HIV-1 infected patients on saquinavir/ritonavir.

Genetic polymorphisms will be investigated by polymerase-chain reaction (PCR) and drug levels of saquinavir will be determined by high phase liquid chromatography with UV-detected (HPLC).

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

HIV Infections

Interventions

identify genetic polymorphism in Thai HIV infectedGENETIC

Gene sequencing of Cyp450 metabolic pathway

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HIV-infected persons who have been enrolled in the Staccato study * On low-dose ritonavir boosted saquinavir at the time blood samples are collected Exclusion Criteria: * Inability to understand the nature and extent of the study and the procedures required

Locations (1)

The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)

Bangkok, Bangkok, Thailand

Data from ClinicalTrials.gov

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