Efficacy Safety Study Comparing 2 Doses of NVP After Initiating Rifampin-containing TB Therapy

Inclusion Criteria: 1. Confirmed HIV positive after voluntary counseling and testing 2. Aged 18-60 years of age 3. Antiretroviral treatment naïve. 4. CD4+ cell count of \< 200 cells/mm3 at the time of diagnosed TB 5. TB is diagnosed and using treatment with rifampin base therapy for at least 2 weeks but no longer than 4 weeks duration. The requirement for study entry is at least one acid-fast bacillus (AFB) positive smear with a typical syndrome and/or CXR findings consistent with pulmonary TB. Pulmonary TB and / or extra pulmonary TB will be included if AFB or culture for TB is positive. 6. No other active OI (CDC class C event) 7. Negative pregnancy test in females, and willing to use reliable contraception 8. Able to provide written informed consent. Exclusion Criteria: 1. The following laboratory variables, i. absolute neutrophil count (ANC) \< 1000 cells/uL ii. hemoglobin \< 6.5 g/dL iii. platelet count \< 50,000 cells/uL iv. serum AST, ALT \> 5 x ULN vi. serum bilirubin \> 2 x ULN vii. serum creatinine \> 2 x ULN viii. Pregnant or nursing mothers. 2. Current use of steroid and other immunosuppressive agents. 3. Current use of any prohibited medications related to compliance and drug pharmacokinetics (see appendix ) 4. Acute therapy for serious infection or other serious medical illness (in the judgment of the site Principal Investigator) requiring systemic treatment and/or hospitalization. 5. Patients with current alcohol or illicit substance use that in the opinion of the site Principal Investigator would conflict with any aspect of the conduct of the trial. 6. The persons who had been received a mono-therapy of nevirapine 7. Unlikely to be able to remain in follow-up for the protocol defined period. 8. Patients with chronic active liver disease. 9. Patients with proven or suspected acute hepatitis. Patients with chronic viral hepatitis are eligible provided ALT, AST \< 5 x ULN. 10. Karnofsky performance score \<30%