Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Universita di Verona

Overview

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Chronic Heart Failure

Interventions

allopurinolDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic heart failure; * left ventricular systolic dysfunction (ejection fraction \<45%) * stable clinical conditions in the previous three months * optimal medical therapy for CHF * normal sinus rhythm * written informed consent * age \>18 years Exclusion Criteria: * renal failure (s-creatinine \>2.5 mg/dl) * already on allopurinol * malignancies * chronic inflammatory diseases

Locations (1)

Division of Cardiology, University Hospital of Verona

Verona, Italy

Outcomes

Primary Outcomes

diastolic function uric acid levels BNP

Time frame: three months

Data from ClinicalTrials.gov

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