RATIONALE: A study that assesses the ability of older patients to think, learn, remember, make judgments, and carry out daily activities may help doctors plan treatment for older patients with cancer. PURPOSE: This clinical trial is studying an assessment tool in older patients with cancer.
OBJECTIVES: Primary * Determine whether a geriatric assessment tool can predict toxicity to chemotherapy, defined as grade 3 or 4 toxicity, hospitalization, dose delay or reduction, or discontinuation of chemotherapy due to toxicity, in elderly patients with cancer. Secondary * Explore the longitudinal impact of cancer and chemotherapy treatment on geriatric assessment parameters. OUTLINE: Patients undergo assessments of functional status using the Timed Up and Go Assessment (measures physical mobility) and Karnofsky Physician-Rated Performance Rating Scale; and cognition using the Blessed Orientation-Memory-Concentration Test. These assessments are performed by healthcare personnel. Body mass index and the percentage of unintentional weight loss and the number of falls in the past 6 months are also assessed. Patients also complete the following self-administered questionnaires: Instrumental Activities of Daily Living (measures level of functioning and need for services); Activities of Daily Living (measures higher levels of physical functioning); Karnofsky Self-Reported Performance Rating Scale (related to survival and clinically significant illness); Physical Health Section of the Older American Resources and Services Questionnaire (measures comorbidity and the impact on daily activities); Hospital Anxiety and Depression Scale; Medical Outcomes Study (MOS) Social Activity Limitations Measure (measures the impact of cancer on patients' social functioning); and MOS Social Support Survey Emotional/Information and Tangible Subscales (measures perceived availability of social support). Patients then begin planned chemotherapy. After completion of chemotherapy (or a maximum of 12 months from study entry), patients undergo assessments and complete self-administered questionnaires as described above. PROJECTED ACCRUAL: A total of 750 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
1,062
Questionnaire administered prior to chemotherapy and within 30 days of completion of chemotherapy.
Cognitive assessment to be obtained prior to chemotherapy and within 30 days of completion of chemotherapy.
Psychosocial assessment and care to be obtained prior to chemotherapy and within 30 days of completion of chemotherapy.
Tower Cancer Research Foundation
Beverly Hills, California, United States
City of Hope Medical Center
Duarte, California, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Orange, California, United States
Ability to predict toxicity to chemotherapy, defined as grade 3-4 toxicity, hospitalization, dose delay or reduction, or discontinuation of chemotherapy due to toxicity, as measured by a geriatric assessment tool
Time frame: Prior to chemotherapy and within 30 days of completion of chemotherapy.
Longitudinal impact of cancer and chemotherapy treatment on geriatric assessment parameters
Time frame: Prior to chemotherapy and within 30 days of completion of chemotherapy.
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