Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

University of Aarhus8 enrolled

Overview

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Insulin Resistance

Interventions

Physiological Bolus of Growth HormoneDEVICE

0,5 mg Norditropin

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Healthy * Age between 18 and 30 years * BMI ≤ 26 Exclusion Criteria: * Known present disease including diabetes mellitus * BMI \> 26 * Uses any medication * Consumes \> 21 units of alcohol per week

Locations (1)

Department M (endocrinology and diabetes)

Aarhus, Aarhus, Denmark

Outcomes

Primary Outcomes

PI3-kinase activity i muscle tissue

Time frame: 2 hours

Secondary Outcomes

Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue

Time frame: 2 hours

Data from ClinicalTrials.gov

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