Diagnostic Outcome Trial in Heart Failure (DOT-HF Trial)

Inclusion Criteria: * Subjects of both genders with mild to severe HF as defined as NHYA Class II to IV who also have an indication for device implant according to ESC/AHA guidelines as well as having a HF hospitalization or Emergency Department visit necessitating therapy within the past 12 months and who meet all inclusion criteria and no exclusion criteria, are eligible for this study. Exclusion Criteria: * Subject is post heart transplant or actively listed on the transplant list and reasonable probability (as defined by investigator) of undergoing transplantation in the next year * Subject received a coronary artery bypass graft or valve surgery in last 90 days * Subject with a myocardial infarction (MI) in the last 40 days. * Subject's life expectancy is less than one year in the opinion of the physician * Subject has severe Chronic Obstructive Pulmonary Disease (COPD), as determined by physician and documented in medical records * Subject is listed for valve replacement/valve repair * Subject has severe, primary pulmonary hypertension as determined by physician and documented in medical records * Subject with serum creatinine ≥ 2.5 mg/dL measured within 14 days prior to enrolment * Subject on chronic renal dialysis * Subject on continuous or uninterrupted (≥ 2 stable infusions per week) infusion (inotropic) therapy for HF * Subject has complex and uncorrected Congenital Heart Disease