Functional Neuroimaging Effects of Cognitive Remediation Training

University of Minnesota30 enrolled

Overview

The purpose of this study is to examine behavioral and functional brain changes occuring as a result of cognitive remediation training in patients with schizophrenia. Extension and specificity of related changes will also be examined.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Schizophrenia

Interventions

Cognitive RemediationBEHAVIORAL

Cognitive Behavioral Social Skills TrainingBEHAVIORAL

Retest in Health ControlsOTHER

Pre/Post test performance and neuroimaging only

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of schizophrenia or schizoaffective disorder * Stable outpatient Exclusion Criteria: * Current drug abuse or dependence * History of neurological damage, disorder, or disease

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Working Memory performance

N-Back Performance

Time frame: Post-test

Brain activation

Changes in prefrontal cortical functioning

Time frame: Post-test

Data from ClinicalTrials.gov

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