Ablation for ICD Intervention Reduction in Patients With CAD

National Institute of Cardiology, Warsaw, Poland200 enrolled

Overview

The aim of this study is to assess the role of ablation in appropriate ICD interventions reduction in patients with coronary artery disease. The group will consist of 200 patients with implanted ICD and appropriate intervention in the 3 months prior to enrollment. The patients will be randomized into ablation arm and conventional treatment. Number of appropriate ICD interventions is the primary endpoint of this study. All patients will have control follow-up visits every 3 months. The follow-up will be based on ICD memory.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Ventricular Tachycardia Coronary Artery Disease Implantable Cardioverter-Defibrillator

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary Artery Disease * ICD implanted * Appropriate ICD intervention during the 3 months prior to enrollment * Coronary angiography during the 6 months prior to enrollment * Possible revascularization * Age over 18 years * Signed informed consent Exclusion Criteria: * Age less then 18 years * Pregnancy * Active participation in other trial * Heart failure (NYHA IV) * Contraindications for ablation procedure: i.e. left ventricular thrombus, artificial aortic or mitral valve, no vascular access. * Monomorphic, incessant, ventricular tachycardia * Revascularization or other cardio-surgical procedure scheduled in the next 6 months

Outcomes

Primary Outcomes

Number of appropriate ICD interventions

Secondary Outcomes

Overall mortality

Cardiac mortality

Hospitalization due to arrhythmia or heart failure

Quality of life