Phenylephrine Versus Norepinephrine in Septic Shock

University of Roma La Sapienza15 enrolled

Overview

Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

PhenylephrineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clical diagnosis of Septic Shock * norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg). Exclusion Criteria: * Age \< 18 years * Pregnancy * Present or suspected acute coronary artery disease * Present or suspected acute mesenteric ischemia.

Locations (1)

Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza"

Rome, Italy

Outcomes

Primary Outcomes

Systemic and regional hemodynamics

Time frame: 24 hours

Secondary Outcomes

Organ functions, adverse effects

Time frame: 24 hours

Data from ClinicalTrials.gov

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