Study of the Safety of VB6-845 in Patients With Advanced Solid Tumours of Epithelial Origin

Inclusion Criteria: Disease Characteristics: * The patient must have locally advanced and/or metastatic solid tumour of epithelial origin for which standard therapy has failed or does not exist; * The patient must have immunohistochemically-confirmed EpCAM positive disease; Patient Characteristics: * The patient must be male or female 18 years of age or older; * The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 and life expectancy ≥ 12 weeks * The patient must have adequate organ function, as defined by the protocol * Female patients with reproductive potential must have a negative serum pregnancy test within 7 days prior to the first dose of the study drug; Other: * The patient must be able to understand and willing to sign an Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved informed consent document indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the trial prior to enrollment * The patient must be willing and able to comply with scheduled visits, the treatment plan, laboratory tests, and other study procedures Exclusion Criteria: * The patient has had treatment with any investigational agent within 4 weeks, or treatment with radiation therapy to a visceral organ, immunotherapy, biological therapy, or chemotherapy within 2 weeks prior to the first dose of study medication * The patient has not adequately recovered from the toxic effects of previous therapy, except treatment-related anemia otherwise meeting the inclusion requirements stated above in inclusion number 5 or alopecia; * The patient has known clinically significant brain metastases or leptomeningeal disease (baseline computed tomography \[CT\] or magnetic resonance imaging \[MRI\] of the brain is only required if there is clinical suspicion of central nervous system involvement); * The patient has experienced a previous significant hypersensitivity reaction; * The patient has known acquired immune deficiency disease or has active hepatitis virus C (HVC) or active hepatitis virus B (HVB); * The patient is pregnant or breast feeding; female patients will be required to be surgically sterile, agree to use double barrier contraception, or commit to abstinence during the period of therapy; male patients will be required to be surgically sterile, use double barrier contraception, or commit to abstinence during the period of therapy * The patient has uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, clinically significant cardiac arrhythmia, or psychiatric illness or social situations that would limit compliance with study requirements.