Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients

Inclusion Criteria: * Men or women age 18 years or older * Referred for cardiac surgery requiring the use of CPB. * Elective or urgent surgeries (non emergency operations). * LVEF ≥40 based on cardiac catheterization results * Normal renal function at study entry * Normal hepatic function (within normal laboratory ranges) at study entry * Normal coagulation status at study entry as judged by PT, PTT, fibrinogen and platelet count. * Willingness to participate in the study and adhere to the study design. * Willingness to sign an informed consent form. Exclusion Criteria: * Emergency operation * Pulmonary hypertension (PA systolic pressure \>60 mmHg) * Ejection fraction less than 35% during weaning from bypass or cardiac index of less than 1.8 * Neurological events such as prior CVA, TIA or symptomatic carotid stenosis within 1 year of presenting for surgery * Body weight \<40 Kg * Pregnancy * Malignancy within 1 year of presenting for surgery * Systemic infection as evidenced by elevated WBC or fever \>38.5 C * Usage of vasoactive medications within 24 hours except short term use of a vasoconstrictor during induction. * Participation in any other investigational drug or device study within 30 days of randomization