Systematic Pelvic Lymphadenectomy Versus no Lymphadenectomy in Clinical Stage I-II Endometrial Cancer

University of Roma La Sapienza

Overview

The purpose of this trial is to determine whether the addition of systematic pelvic lymphadenectomy to hysterectomy with bilateral adnexectomy improves disease-free survival (DFS) and overall survival (OS) in patients with preoperatively supposed Stage I-II endometrial cancer

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Endometrial Cancer

Interventions

Systematic pelvic lymphadenectomyPROCEDURE

Eligibility

Sex: FEMALEMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically proven endometrioid or adenosquamous endometrial carcinoma. * Patients having myometrial invasion * Age =/\< 75 years * Informed consent. Exclusion Criteria: * Serous papillary and clear cell tumors. * Karnofsky index \< 80 or severe diseases contraindicating surgery * Concomitant neoplasia (basalioma cutis excluded) * Distant metastasis or abdominal metastasis detected intraoperatively. * Absence of myometrial invasion at frozen section.

Data from ClinicalTrials.gov

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