Efficacy, Pharmacokinetics and Safety of Org 25969 in Subjects With Normal or Impaired Renal Function (19.4.304)(P05948)(COMPLETED)

Inclusion Criteria: * ASA class 1 - 3 for renally impaired patients, ASA class 1-2 for control group * Age at least 18 years * Scheduled for general anesthesia without further need for muscle relaxation other than one single dose of 0.6 mg.kg-1 rocuronium * Scheduled for surgical procedures in the supine position * Written informed consent * Creatinine clearance (CLCR) \< 30 mL/min for renally impaired group, CLCR = 80 mL/min for control group Exclusion Criteria: * Known or suspected neuromuscular disorders impairing NMB * Known or suspected (family) history of malignant hyperthermia * Known or suspected allergy to narcotics, muscle relaxants or other medication used during general anesthesia * Use of medication known to interfere with NMBA based on the dose and the time of administration, such as antibiotics, anticonvulsants and Mg2+ * Pregnancy * Childbearing potential without using any of the following methods of birth control: condom or diaphragm with spermicide, vasectomized partner ( \> 6 months), intrauterine device, abstinence * Breast-feeding * Prior participation in any trial with Org 25969 * Participation in another clinical trial, not pre-approved by NV Organon, within 30 days of entering into trial 19.4.304, or for the UK only: Participation in another clinical trial, within 30 days of entering into trial 19.4.304.