Effect of a Nasal Bolus Allergen Challenge on Inflammatory Markers

Pfizer6 enrolled

Overview

The current study will investigate nasal inflammatory markers obtained by filter paper collection techniques, in subjects with allergic rhinitis, determining the most appropriate time points and handling conditions, prior to running a larger study with subjects with allergic rhinitis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Seasonal Allergic Rhinitis

Interventions

Intra-nasal allergen challenge with Phleum pratense.PROCEDURE

Collection of nasal effluent using filter paper.PROCEDURE

Measurement of nasal congestion using acoustic rhinometry.PROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female subjects with allergic rhinitis, that have a positive skin prick response to Phleum pratense. Exclusion Criteria: * Subjects with a history of asthma. Current smokers, or recent ex-smokers and subjects that have had a respiratory tract infection in the previous 4 weeks.

Locations (1)

Pfizer Investigational Site

London, England, United Kingdom

Outcomes

Primary Outcomes

Post allergen challenge nasal inflammatory markers at 1, 5, 15, 30, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge.

Secondary Outcomes

Post allergen challenge effects on acoustic rhinometry and symptoms at 16, 31, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.