Treatment of Hyperglycaemia and Insulin Resistance in HIV Infected Patients

Inclusion Criteria: * documented HIV infection * stable Protease Inhibitor containing HAART regimen for at least 12 months * impaired glucose tolerance * elevated insulin levels (above 20 mIU/l) Exclusion Criteria: * patients already taking oral hypoglycaemic treatment or insulin * heart failure NYHA I-IV * liver disease or kidney disease * elevated AST or ALT above 2 times upper normal range * elevated creatinine (above 150 mmol/l)