Alterations of Immunologic Mediators During Severe Sepsis

Klinikum St. Georg gGmbH20 enrolled

Overview

Severe sepsis induces significant changes in expression of insulin- and toll-like receptors, cytokines, markers of apoptosis, and activation of t- and b-lymphocytes.

In patients at early stage of severe sepsis, we investigate the expression of pro- and anti-inflammatory cytokines, chemokines, adhesion-molecules, toll-like receptors, insulin-receptors, markers of apoptosis und of t- and b-cell-activation on a mRNA level.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Severe Sepsis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \>= 18 y * agreement with study procedures * 3 of 4 SIRS-criteria * proven or highly suspected infection * 2 or more sepsis-induced organ failures * start of first sepsis-induced organ failure within the last 36 hours Exclusion Criteria: * non-agreement with study procedures * signs of severe sepsis with organ failure \> 36 hours * chronic immuno-compromising diseases * chronic therapy with anti-inflammatory drugs * non-curable cancer * chronic renal failure with hemodialysis * pregnancy or breast-feeding

Locations (1)

Klinikum St. Georg gGmbH, Interdisciplinary Intensive Care Unit

Leipzig, Saxony, Germany

Outcomes

Primary Outcomes

severity of sepsis

SOFA-Score

Time frame: 96 hours after diagnosis of sepsis

Data from ClinicalTrials.gov

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