Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition

Zentrum für Integrative Psychiatrie

Overview

15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A and approximately two weeks later placebo or vice versa. Thereafter sleep will be recorded, the cytokine-system and neurocognition characterized.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Conditions

Narcolepsy

Interventions

Orexine ADRUG

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Narcolepsy * Age \>18 * Informed consent * GERMAN fluently spoken Exclusion Criteria: * Additional severe psychiatric or somatic disorders * Pregnancy or nursing * Anemia (Hb\<10g/dl)

Locations (1)

Zentrum für Integrative Psychiatrie

Kiel, Germany

Outcomes

Primary Outcomes

Effect of orexine A on sleep, neurocognition and immune-system

Data from ClinicalTrials.gov

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