Effect of Meal on Portal and Esophagus Variceal Pressure

Hvidovre University Hospital

Overview

The reason why esophagus varices suddenly rupture and start to bleed is unclear. Food intake increase the hepatic blood flow and the portal pressure, but it is yet unknown if there is also an increase in variceal pressure. The aim of this study is to evaluate the efficacy of a meal on variceal pressure with a non invasive endoscopic measurement device, and compare it with portal pressure.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Conditions

Cirrhosis Esophageal Varices

Interventions

meal (food intake)BEHAVIORAL

600 kcal. (16% protein, 49%carbohydrate, 35% fatt)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Large Esophageal varices Exclusion Criteria: * Treatment with beta-blocking agents * Respiratory diseases that contradict endoscopy * Gastric-retention * Former gastric resection * Resent sclerotherapy or former banding

Locations (1)

Hvidovre Hospital

Hvidovre, Denmark

Outcomes

Primary Outcomes

effect of meal on variceal pressure

Time frame: 30 minutes after the meal

Data from ClinicalTrials.gov

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