Pregnancy Outcomes With a GnRH Antagonist Protocol Versus GnRH-Agonist Protocol in ICSI Cycles

Clinic and Research Center in Human Reproduction Roger Abdelmassih2,005 enrolled

Overview

Cycles with GnRH agonist and GnRH antagonist were compared and main outcome measures were the number of oocytes retrieved, injected and fertilized, embryos transferred, and clinical pregnancy and miscarriage rates, were analized.

160 women were equally divided between a GnRH antagonist protocol (Group 1) versus a GnRH agonist protocol (Group 2) in ICSI cycles. The trial was conducted between September 2005 and December 2006. The mean age in both groups was 32 (range 22-40). The main outcome measures were the number of oocytes retrieved, injected and fertilized, embryos transferred, and clinical pregnancy and miscarriage rates.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

2,005

Conditions

Infertility

Interventions

oocyte retrieval and ICSI procedurePROCEDURE

Eligibility

Sex: FEMALEMin age: 22 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infertility couples, absence of endometriosis (confirmed by a previous surgical procedure to investigate infertility), polycystic ovarian syndrome, FSH levels \< 12 IU/l, basal levels of estradiol \< 20 in the group submitted to the agonist protocol and beginning of stimulation on day 2 in group submitted to antagonist protocol, in the absence of ovarian cysts on the endovaginal ultrasound Exclusion Criteria: * use of exogenous LH during stimulation

Locations (1)

Clinica e Centro de Reprodução Humana Roger Abdelmassih

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Comparative response to ICSI cycles with GnRH agosnist and cetrotide

Time frame: 16 months

Secondary Outcomes

Compare number of oocytes retrieved, injected and fertilized, embryos transferred, and clinical pregnancy and miscarriage rates in both groups

Time frame: 16 months

Data from ClinicalTrials.gov

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