Effect of Testosterone Replacement on Insulin Resistance

Inclusion Criteria: (subjects must meet both criteria) * Metabolic syndrome (have 3 out of the following 4 criteria): 1. BP \> 130/85 or on antihypertensive therapy 2. Fasting glucose \> 100 mg/dl 3. Fasting TG \> 150 mg/dl or on a triglyceride lowering agent (fenofibrate, gemfibrozil, niacin in doses of \>= 500 mg/day, or fish oils in doses of \>=2000mg DHA+EPA) 4. Fasting HDL-C \< 40 mg/dl Note that the waist circumference will not be used as one of the criteria for the metabolic syndrome for this study because we are studying non-obese subjects. * Total Testosterone less than 300 ng/dl Exclusion Criteria: * Women. * Men less than 20 years of age. * BMI \> or = to 30 kg/M2. * Use of testosterone preparations within 1 year of the screening visit * Use of hypoglycemic medications within the previous 3 months. * Fasting blood glucose \> 126 mg/dl. * The following men will be excluded because of the potential safety issues in the placebo treated group: 1. Creatinine greater than 1.4 mg/dl 2. Triglyceride levels greater than 500 mg/dl 3. HDL-C levels less than 20 mg/dl 4. Blood pressure greater than 160/90 * The following men will be excluded because of the potential side effects of testosterone therapy: 1. Men greater than 65 years of age 2. International prostate symptom score \>19 3. PSA greater than 2.5 4. History of benign prostatic hypertrophy 5. History of prostate cancer 6. Abnormal digital rectal exam 7. Hg greater than 16 mg/dl or Hct greater than 48% 8. peripheral edema