Single Group Study of the Safety of and Immune Response to a Bird Flu Virus Vaccine (H5N1) in Healthy Adults

Inclusion Criteria: * Good general health * Available for the duration of the study * Willing to use acceptable forms of contraception for the duration of the study Exclusion Criteria: * Clinically significant neurologic, heart, lung, liver, rheumatologic, autoimmune, or kidney disease * Behavioral or cognitive impairment or psychiatric disease that, in the opinion of the investigator, may affect study participation * Medical, work, or family problems as a result of alcohol or illicit drug use within 12 months prior to study entry * Previously enrolled in an H5N1 influenza vaccine trial or in any study of an avian influenza vaccine * Seropositive to the H5N1 influenza A virus (serum hemagglutination inhibitor \[HI\] titer greater than 1:8) * Illegal drug use or dependency determined by urine test * History of severe allergic reaction * Allergy to oseltamivir * Asthma or reactive airways disease within 2 years prior to study entry * History of Guillain-Barre syndrome * HIV infected * Hepatitis C virus infected * Positive for hepatitis B surface antigen (HBsAg) * Known immunodeficiency syndrome * Use of corticosteroid or immunosuppressive drugs within 30 days prior to vaccination. Participants who have used topical corticosteroids are not excluded. * Live vaccines within 4 weeks prior to study vaccination * Killed vaccines within 2 weeks prior to study vaccination * Absence of spleen * Blood products within 6 months prior to study vaccination * Current smoker unwilling to stop smoking for the duration of the study * Have traveled to the Southern Hemisphere or Asia within 14 days prior to study vaccination * Have traveled on a cruise ship within 14 days prior to study vaccination * Work in the poultry industry * Other investigational vaccine or drug within 30 days prior to study vaccination * Allergy to eggs or egg products * Purified protein derivative (PPD) positive (positive tuberculosis \[TB\] test) * Have family member with immunodeficiency-related condition * Other condition that, in the opinion of the investigator, may interfere with the study * Pregnancy or breastfeeding