The aim of this study is to compare the effect of montelukast and cetirizine on allergic inflammation measured by exhaled nitric oxide concentration in children with seasonal allergic rhinitis.
During the pollen season children with seasonal allergic rhinitis without concomitant asthma are at risk of having allergic inflammation in the lower respiratory tract. About 60% of children with seasonal allergic rhinitis present bronchial hyperresponsiveness and signs and symptoms of asthma. The aim of this study is to compare the effect of montelukast and cetirizine on allergic inflammation measured by exhaled nitric oxide concentration in children with seasonal allergic rhinitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
116
Department of Pediatrics and Allergy, Medical University of Lodz Lodz, Poland
Lodz, Poland
RECRUITINGexhaled nitric oxide concentration
Time frame: baseline (first visit), after 4 weeks (second visit) and after 6 weeks from second visit (third visit)
symptoms score (based on PAQLQ), bronchial hyperresponsiveness with methacholine, spirometry, PEFR measurements
Time frame: baseline (first visit), after 4 weeks (second visit) and after 6 weeks from second visit (third visit)
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