Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee

Inclusion Criteria: * Patient is 18 through 75 years of age * Patient has radiographic evidence of osteoarthritis of the target knee obtained within the past year. Exclusion Criteria: * Patient has a known allergy to nonsteroidal anti-inflammatory drugs (NSAIDs, including aspirin). * Patient has asthma that has been induced or made worse by the use of aspirin or NSAIDs. * Patient has a relevant history of serious gastrointestinal disease. * Patient, if female, is pregnant or breastfeeding or is of childbearing potential and not practicing adequate birth control. * Patient is taking warfarin, heparin, or low molecular weight heparin. * Patient has received oral, intramuscular, intravenous, intra-articular, or soft-tissue administration of steroids within 1 month of study enrollment (or within 2 months, if in the target joint). * Patient has received intra-articular visco-supplementation (in target joint) within 6 months of study enrollment.