Assessment of Pulmonary Involvement inUlcerative Colitis by Induced Sputum

Hillel Yaffe Medical Center20 enrolled

Overview

Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessment of pulmonary involvement in Crohn's disease by induced sputum. Am J Gastroenterol 2000;95(30):730-734. )

Twenty Ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. The induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. Samples will studied by differential counts of 200 cells on cytopreps stained by Giemsa. T-lymphocyte subset analyses were done by FACS using three monoclonal antibodies: CD3 = total T cells, CD4 = T helper cells, and CD8 = T suppressor-cytotoxic cells. CD4/CD8 \>2.5 was considered abnormal.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Ulcerative Colitis

Interventions

Induced sputum (inhalation of 3.5% saline)PROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All the ulceratvive colitis patients without lung involvmentage 18-75 years of age Exclusion Criteria: * Pregnant women * Non cooperative patients * Smoker * Lung disease

Outcomes

Primary Outcomes

lung involvment in Ulcerative colitis patients

Data from ClinicalTrials.gov

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