Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer

Stanford University72 enrolled

Overview

This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.

The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neoplasms

Eligibility

Sex: ALLMin age: 9 YearsMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

INCLUSION Everyone: * At least 9 years of age and less than 17 years Patients * Diagnosis of brain tumor or acute lymphocytic leukemia (ALL) * Completed all anti-cancer treatment(s) including chemotherapy, radiation and/or surgery Control group * Typical for age EXCLUSION Everyone: * Non-English speaking (translated cognitive testing and MRI assessments unavailable) * MRI contraindication, including but not limited to orthodontia, metal implants, and/or pacemaker * Major sensory deficit disorders, including but not limited to blindness or deafness Patients * Shunt placement * Received bone marrow transplant * History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes) NOT related to cancer * Participation in any concurrent cognitive rehabilitation study Control group * History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes)

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

Performance on neuropsychological testing and brain activation patterns measured by functional MRI

Time frame: 8 weeks

Data from ClinicalTrials.gov

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