Neoadjuvant Chemotherapy for Resectable Cancer of the Pancreatic Head

Inclusion criteria: - Age \> 18 years * Histologically or cytologically confirmed resectable ductal adenocarcinoma of the pancreatic head * WHO-performance status 0-2 * Written informed consent * Discussion in an intrdisciplinary conference Exclusion criteria: - Insufficient renal function (calculated creatinin clearance \< 60ml(min) * Insufficient hematologic function (neutrophil count \<1'000/ul, platelets \< 100'000/ul) * Uncorrectable coagulopathy * Severe cholestasis (bilirubin \>100mmol/l) * Distant metastases in liver, lungs or other organs * Peritoneal carcinomatosis * Unresectable tumor (s. 4.2.) * Contraindication for Whipple procedure * Uncontrolled infection * Neurotphil count \> °2 * Estimated life experience \< 6 months * HIV Infection * Severe medical or psychatric comorbidities which interefere with the participation in this trial or the informed consent * Female patients in child-bearing age without adequate contraception