Pharmacokinetic and Efficacy Study of Fluocinolone Acetonide Inserts in Patients With Diabetic Macular Edema

Inclusion Criteria: * Age \>= 18 years with diabetic macular edema * Diagnosis of diabetes mellitus types 1 or 2 * Best corrected visual acuity of ≥ 19 letters * Retinal thickness \> 250 microns by OCT * Investigator is comfortable deferring macular laser treatment for 6 weeks Exclusion Criteria: * Glaucoma, ocular hypertension, IOP \>21 mmHg or concurrent therapy at screening with IOP lowering agents * Retinal or choroidal neovascularization due to ocular conditions other than diabetic retinopathy * Prior intravitreal, subtenon, or periocular steroid therapy within the last 3 months * Prior intravitreal or subtenon anti-VEGF therapy within the last 2 months * Any ocular surgery within the last 3 months * Retinal laser treatment within the last 3 months * History of uncontrolled IOP elevation with steroid use that did not respond to topical therapy * Any lens opacity which impairs visualization of the posterior pole