Phototherapeutic Keratectomy (PTK) With Mitomycin in Adenoviral Opacities

Federal University of São Paulo30 enrolled

Overview

The present study was designed to evaluate the treatment of adenoviral corneal opacities with PTK and mitomycin C.

Epidemic keratoconjunctivitis is a very common disease, some patients developed a complication after the infection wich is corneal infiltration. Topical treatment sometimes helps to avoid loss of visual acuity. Therefore recurrence of the opacities after topical drops is observed. When corneal fibrosis occur is difficult to achieve visual rehabilitation with topical approach. This study evaluate pre and postoperative data of patients with subepithelial fibrosis caused by adenoviral infiltrates submitted to phototherapeutic keratectomy (PTK) using mitomycin C.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Keratitis Corneal Opacity

Interventions

PTK with mitomycin in Adenoviral OpacitiesPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * visual acuity worse than 20/40, caused by central subepithelial fibrosis Exclusion Criteria: * pregnancy, age less than 18 years-old or more than 80 years-old. * diabetes, autoimmune diseases, corneal thickness less tha 400 micron.

Locations (1)

Federal University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Refractive data, visual acuity, slit lamp findings, subjective evaluation, topography patterns, pachymetry measurements.

Time frame: one year

Secondary Outcomes

wavefront analysis, anterior segment tomography data, corneal biomechanics data.

Time frame: one year

Data from ClinicalTrials.gov

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