What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?

University Hospital, Gasthuisberg300 enrolled

Overview

The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is higher when the cycle is started with daily, small-dose hormonal injections than in cycles without these daily injections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

300

Conditions

Infertility

Interventions

human menopausal gonadotrophinsDRUG

Daily subcutaneous injections, dose 37.5 IU or 75 IU, start on day 2 of the menstrual cycle until ovulation

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Signed informed consent. * Women with a regular cycle (between 21 and 35 days). * Embryos with 50% intact blastomeres after thawing. * Embryo and endometrium are synchronized. Exclusion Criteria: * Embryo storage time not longer than 5 years.

Locations (1)

Leuven University Fertility Center

Leuven, Vlaams Brabant, Belgium

Outcomes

Primary Outcomes

implantation rate per embryo

Time frame: 15 days after the embryo transfer

Secondary Outcomes

thickness of the endometrium

Time frame: 0-2 days before the human chorionic gonadotropin (hCG) injection

Data from ClinicalTrials.gov

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