Different Regimens of Transarterial Chemoembolization for Hepatocellular Carcinoma

Inclusion Criteria: * Adult patients with minimal height of 150cm and minimal weight of 50 KG * Histological confirmed HCC * with no previous treatment * With unresectable tumor * With solitary or multiple intrahepatic tumor, the diameter of the largest one must larger than 7cm. * No significant baseline liver dysfunction. Cirrhotic status of Child-Pugh class A only * No significant renal impairment (creatinine clearance \< 30 mL/minute) * The following laboratory parameters: * Platelet count ≥ 60,000/µL * Hemoglobin ≥ 8.5 g/dL * Total bilirubin ≤ 1.5 mg/dL * ASL and AST ≤ 5 x upper limit of normal * Serum albumin ≥ 35 g/L * Serum creatinine ≤ 1.5 x upper limit of normal * INR ≤ 1.5 or a Pt/PTT within normal limits * Absolute neutrophil count (ANC) \> 1,500/mm3 * Ability to understand the protocol and to agree to and sign a written informed consent document Exclusion Criteria: * Avascular tumor * Main portal vein obstruction without cavernous transformation * Evidence of hepatic decompensation including esophageal or gastric variceal bleeding or hepatic encephalopathy * Obstructive jaundice * Severe underlying cardiac or renal diseases * Known or suspected allergy to the investigational agent or any agent given in association with this trial * Pregnant or breast-feeding patients. * History of organ allograft * Active clinically serious infections * Any condition that is unstable or which could jeopardize the safety of the patient and his/her compliance in the study