ZK219477 (Sagopilone) in Patients With Breast Cancer and Brain Metastases

Inclusion Criteria: * Patients must have histologically or cytologically invasive breast cancer, with metastatic disease at the time of screening * Measurable Central Nervous System (CNS) disease, as defined as at least one lesion \> or equal too 10mm in longest dimension * New or progressive CNS lesions after at least one prior standard CNS-directed therapy for treatment of brain metastases, which could include surgical resection, whole brain radiotherapy (WBRT), and/or stereotactic radiosurgery (SRS). Patients must have received prior WBRT, SRS or both. * Patient has been evaluated by a radiation oncologist, who feels that the plan to evaluate systemic chemotherapy in place of additional brain radiotherapy is an acceptable option * No increase in corticosteroid use in the week prior to study entry * Any number prior lines of chemotherapy for metastatic breast cancer * 18 years of age of older * Life expectancy of greater than 12 weeks * ECOG Performance Status 0-2 * Patients must have normal organ function as outlined in the protocol Exclusion Criteria: * Patients who have had chemotherapy within 3 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 3 weeks earlier * Patients who have had XRT within 3 weeks prior to entering the study or those who have not recovered from adverse events due to XRT * Patients may not be receiving any other investigational agent * Patients may not be receiving any cancer-directed therapy * Prior treatment with investigational chemotherapy for brain metastases * Prior treatment with epothilone for metastatic breast cancer * Leptomeningeal carcinomatosis as the only site of CNS involvement. * Concurrent treatment with an enzyme inducing antiepileptic drug, including phenytoin, carbamezepine, phenobarbital, or oxacarbazepine * More than 2 seizures over the last four weeks prior to study entry * Known contraindication to MRI or gadolinium contrast, such as cardiac pacemaker, ocular foreign body, or shrapnel * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Pregnant or breastfeeding women.