Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors

Inclusion Criteria: * Breast cancer survivors (Stage I-III) 2-6 years post all cancer treatments, but currently receiving hormone therapy. * History of treatment with chemotherapy and/or hormonal therapy, or hormone therapy only. * No evidence of active/recurrent disease. * Less than 70 years old at time of recruitment. * Post-menopausal prior to initial treatment. * In the judgment of the consenting professional, is able to provide informed consent. * Patient is able to understand English, through verbal and written communication. Exclusion Criteria: * Recurrence of breast cancer or diagnosis of another cancer except basal cell carcinoma. * Exposure to chemotherapy or radiation therapy for any medical condition unrelated to breast cancer. * Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness \> 60 min or evidence of structural brain changes on imaging). * Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc. * Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome. * Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia. * Disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia. * Male. Healthy Control Inclusion Criteria: * Have had no diagnosis of cancer except basal cell carcinoma. * Less than 70 years old at time of recruitment. * Post-menopausal. * In the judgment of the consenting professional, is able to provide informed consent. * Patient is able to understand English, through verbal and written communication Healthy Control Exclusion Criteria: * Exposure to chemotherapy or radiation therapy for any medical condition. * Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness \> 60 min or evidence of structural brain changes on imaging). * Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis etc. * Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome. * Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia. * Male.