Intranasal ALN-RSV01 Administered to Adult Volunteers Experimentally Inoculated With Respiratory Syncytial Virus

Inclusion Criteria: * Availability for the required study period (including the inpatient phase, ability to comply with study requirements and attend follow-up study visits * Able to provide written consent for participation after reading the Consent Form and after having adequate opportunity to discuss the study with an investigator or qualified deputy. * Good general health status as determined by a screening evaluation no greater than 120 days but not less than 14 days prior to enrollment and admission to the research unit * Low titers of RSV neutralizing antibody measured during screening. Exclusion Criteria: * Significant acute or chronic, uncontrolled medical illness * Presence of household member or close contact to someone who: * Is less than three(3) years of age * Has a known immunodeficiency * Is receiving immunosuppressant drugs * Is undergoing or soon to undergo cancer chemotherapy within 28 days of enrollment * Has diagnosed emphysema, chronic obstructive pulmonary disease(COPD), or severe lung disease * Is elderly and residing in a nursing home, or * Has received an organ transplant * Females are not eligible for this study * Evidence of or history of drug or alcohol abuse (within the past 6 months) or positive urine drug or alcohol screen Other protocol-defined inclusion/exclusion criteria may apply.