Efficacy and Safety of PERIOGEN in the Treatment of Periodontal Bone Defect

Inclusion Criteria: 1. Probing depth ≥7 mm at baseline 2. Presence of ≥4 mm vertical bone defect with at least 1 bony wall after surgical debridement. 3. Adequate keratinized tissue to permit complete tissue coverage of defect. 4. Radiographic base of defect ≥3 mm coronal to the apex of the tooth. Exclusion Criteria: 1. Failure to maintain adequate oral hygiene (plaque index\>2) 2. Pregnant and lactating women 3. History of oral cancer or HIV 4. Periodontal surgery on treatment-targeted tooth within the last year. 5. Tooth mobility greater than grade II. 6. Study tooth exhibiting a class III furacation defect 7. Localized aggressive periodontitis 8. Radiographic signs of untreated acute infection at the surgical site 9. Recent history of smoking more than 20 cigarettes/day 10. Known allergy to E.coli-derived products 11. Using an investigational therapy within the past 30 days.